Table 4

Effects of aldehyde oxidase and xanthine oxidase inhibitors on the formation of 6-oxo-metabolites from 500 μM 6-deoxypenciclovir and famciclovir with partially purified rat liver molybdenum hydroxylases

Inhibitor (conc)	6-Oxo-Metabolite Production (nmol/mg protein/15 min)
	Penciclovir^4-a		6-Oxofamciclovir AO-Active Rat^4-b
	AO-Active Rat	AO-Deficient Rat	6-Oxofamciclovir AO-Active Rat^4-b
Control	79 ± 2	37 ± 16	66 ± 9
Menadione (100 μM)	32 ± 5^4-d	39 ± 17	1 ± 1^4-c
Isovanillin (100 μM)	27 ± 5^4-d	36 ± 5	ND^4-e
Allopurinol (100 μM)	61 ± 2	7 ± 9^4-d	60 ± 4
Menadione plus Allopurinol (100 μM)	0	ND	ND

↵4-a Mean ± SD (N = 3–4).
↵4-b Mean ± SEM (N = 4).
Results are significantly different from control incubations at
↵4-c p < 0.005 and
↵4-d p < 0.05.
↵4-e Not determined.