Table 5

Pharmacokinetic parameters for DZ disposition in UT, PB-treated, and DEX-treated rats

VSS MRTTerminalt1/2PlasmaCLCLint
liters/SRW min min ml/min/SRW ml/min/SRW
UT1.1  ± 0.551.3  ± 31.438  ± 1831  ± 10127  ± 58
PB1.2  ± 0.542.3  ± 18.739  ± 1541  ± 32191  ± 154
DEX0.8  ± 0.310.2  ± 2.7* 21  ± 771  ± 26* 323  ± 108**
  • Data are presented as means ± SD (N = 9 for UT and N = 5 for PB and DEX). Mean significantly different from UT and PB (* p < 0.05). Mean significantly different from UT (** p < 0.05).