Treatment | CLint | ||
---|---|---|---|
In Vivo | Microsomal6-a | Hepatocyte6-a | |
ml/min/SRW | |||
UT | 127 | 54 (43%) | 99 (78%) |
PB | 191 | 68 (36%) | 144 (75%) |
DEX | 323 | 248 (77%) | 297 (92%) |
Numbers in parentheses represent percentage of in vivo CLint.
↵6-a Obtained by scaling in vitro CLint by 513, 513, and 660 mg/SRW for PB, DEX, and UT microsomes, respectively, and 1.2, 1.4, and 1.2 × 109/SRW for PB, DEX, and UT hepatocytes, respectively. UT predictions differ from previous publication (7) due to the use of literature scaling factors in the previous study.