Modulation of microsomal DZ metabolism by 4′-HDZ, 3-HDZ, and NDZ
| Treatment | % Change7-a | ||
|---|---|---|---|
| 4′-HDZ | 3-HDZ | NDZ | |
| UT | −34 ± 3 | −25 ± 6 | −27 ± 2 |
| PB | −64 ± 5 | −46 ± 6 | −50 ± 4 |
| DEX | −66 ± 4 | +31 ± 20 | +141 ± 78 |
Data are presented as means ± SD (N = 4 for each treatment).
↵7-a Refers to change in control rate of DZ depletion (2 μM) in the presence of metabolite (100 μM). Control rates were 0.097 ± 0.004, 0.137 ± 0.008, and 0.155 ± 0.007 nmol/min/mg for UT, PB, and DEX microsomes, respectively.