Kinetic parameters for the oxidative metabolites of carvedilol by human liver microsomes
| Michaelis-Menten Parameter | Apparent Km (μM) | Vmax (nmol/hr/mg) |
|---|---|---|
| R(+)-Carvedilol | ||
| 4OHC | 21, 31, 26 | 10, 12, 8 |
| 5OHC | 31, 42, 36 | 9, 9, 8 |
| 8OHC | 1066, 207, 520 | 91, 24, 49 |
| ODMC | 100, 230, 113 | 12, 18, 11 |
| S(−)-Carvedilol | ||
| 4OHC | 20, 52, 57 | 9, 15, 12 |
| 5OHC | 32, 65, 72 | 7, 9, 8 |
| 8OHC | 60, 38, 123 | 10, 11, 12 |
| ODMC | 195, 176, 239 | 27, 29, 29 |
Values are means of 3 livers ± S.D.