Table 5

Comparison of glucuronidation rates from cynomolgus monkey and human liver microsomes with in vivo duration in both species

Table 5

Structure		UDPGT Rate^5-a		Oral Half-life^5-b
Structure		Monkey	Human	Monkey	Human
1		0.12	0.29	0.4	2.3
18		0.02	0.10	7.7	5.9
19		0.01	0.01	8.7	7.0
20		<0.01	<0.01	16.0	16.0

↵5-a In vitro UDPGT rate (nmol/min/mg protein), where [S] = 100 μM.
↵5-b Plasma half-life after oral dosing (hr).