Table 3

CL_int values and in vitro half-lives for selected progestins, derived from human liver microsomal incubations with either 2 or 15 μM drug concentrations and an incubation time of 60 min

Compound	2 μM		15 μM
Compound	In Vitro CL_int	Scaled In Vivo CL_int	t_1/2	In Vitro CL_int	Scaled In Vivo CL_int	t_1/2
	ml/min/mg	liters/hr	min	ml/min/mg	liters/hr	min
3-Keto-desogestrel	0.02486	104.4	54.6	0.01600	67.2	76.4
Desogestrel	0.01309	55.0	68.8	0.01316	55.3	75.6
Norgestimate	0.06600	277.2	20.8	0.02700	113.4	38.4
Levonorgestrel	0.01729	72.6	78.8	0.01024	43.0	127
Gestodene	0.02471	103.8	47.5	0.00943	39.6	131
Norethisterone	0.01929	81.0	73.7	0.01743	73.2	70
Dienogest	0.01914	80.4	64.9	0.00900	37.8	127