Table 1

Mean ± SD artemisinin pharmacokinetic parameters on days 1, 4, and 7 of a 7-day oral regimen of 500 mg of artemisinin daily to 10 healthy, male Vietnamese adult subjects, of which 7 were restudied on day 21 after a 2-week washout period

Study DayAUCt (hr · ng/ml)Cmax (ng/ml)t1/2(hr)CL/F (liter/hr)
11373  ± 912311  ± 2323.0  ± 1.21-a 502  ± 283
 (754, 1779)(167, 397)(2.0, 3.8)(281, 664)
4402  ± 251148  ± 933.8  ± 2.01-a 3033  ± 4636
(147, 605) (76, 199)(2.3, 5.2) (826, 3398)
7346  ± 398110  ± 1044.8  ± 5.01-b 8048  ± 12895
 (61, 485) (36, 151)(1.2, 9.8)(1031, 8190)
21862  ± 5031-c 195  ± 1261-c 2.7  ± 0.91-c 553  ± 1861-c
 (137, 2180) (61, 361)(1.8, 3.6)(364, 767)

Values in parentheses represent the 95% confidence intervals around the (geometric) averages based on log-normal distributions.

  • 1-a N = 8–9.

  • 1-b N = 5.

  • 1-c N = 6–7.