Table 6

Testosterone metabolism in hepatocytes and liver slices

Tissue SourceTestosterone Metabolism
HepatocytesLiver Slices
μg 6β-hydroxytestosterone/106 cells/30 min
Tx-livers
 Liver 10.12  ± 0.010.15  ± 0.04
 Liver 20.27  ± 0.070.29  ± 0.07
 Liver 31.09  ± 0.20ND6-a
 Liver 4ND0.28  ± 0.07
 Liver 5ND0.43  ± 0.06
 Liver 6ND0.56  ± 0.05
 Mean ± SE0.49  ± 0.300.34  ± 0.07
PH-livers
 Liver 72.38  ± 0.220.28  ± 0.12
 Liver 81.32  ± 0.041.97  ± 0.32
 Liver 9ND0.08  ± 0.02
 Liver 100.53  ± 0.02ND
 Liver 11ND0.07  ± 0.01
 Mean ± SE1.41  ± 0.540.60  ± 0.46

Results are expressed as means of three samples.

  • 6-a ND, not done.