Table 7

Metabolism of 7-EC to 7-HC, 7-HC glucuronide, and 7-HC sulfate in hepatocytes and slices

7-EC Metabolites
7-HC7-HC Glucuronide7-HC Sulfate7-HC Total7-a
nmol/106 cells/hr
Hepatocytes
 Tx-livers1.47  ± 0.51 (5)1.54  ± 0.48 (5)0.72  ± 0.29 (5)3.73  ± 1.01 (5)
 PH-livers0.99  ± 0.19 (4)1.51  ± 0.12 (4)0.07  ± 0.077-b (4)2.57  ± 0.28 (4)
Slices
 Tx-livers2.21  ± 0.39 (10)1.14  ± 0.37 (10)0.37  ± 0.23 (10)3.72  ± 0.72 (10)
 PH-livers0.52  ± 0.157-c (3)0.15  ± 0.127-c (3)ND7-d(3)0.67  ± 0.277-c (3)

Results are expressed as means ± SE (N).

  • ↵7-a 7-HC + 7-HC glucuronide + 7-HC sulfate.

  • ↵7-b p < 0.05 vs. Tx-livers.

  • ↵7-c p < 0.05 vs. Tx-liver and PH-liver hepatocytes.

  • ↵7-d ND, not detectable.