GFR and renal clearance1-a
Drug | Renal Clearance | ||
---|---|---|---|
Rat (GFR = 8.7 ml/min/kg) | Human (GFR = 1.8 ml/min/kg) | Rat/Human Ratio (GFR Ratio = 4.8) | |
β-lactam antibiotics | |||
Cefoperazone | 4.7 | 1.2 | 3.5 |
Moxalactam | 15 | 3.0 | 5.0 |
Cefpriramide | 6.2 | 1.8 | 3.7 |
H2-receptor antagonists | |||
Famotidine | 28 | 4.5 | 6.2 |
Cimetidine | 35 | 7.0 | 5.0 |
ACE inhibitors | |||
Enalaprilat | 18 | 3.1 | 5.8 |
Lisinopril | 11 | 1.7 | 6.5 |
Anticancer drugs | |||
Methotrexate | 10 | 1.6 | 6.2 |
ACE, angiotensin-converting enzyme.
↵1-a Adapted from Lin, 1995.