Table 1

GFR and renal clearance1-a

DrugRenal Clearance
Rat (GFR = 8.7 ml/min/kg)Human (GFR = 1.8 ml/min/kg)Rat/Human Ratio (GFR Ratio = 4.8)
β-lactam antibiotics
 Cefoperazone4.71.23.5
 Moxalactam153.05.0
 Cefpriramide6.21.83.7
H2-receptor antagonists
 Famotidine284.56.2
 Cimetidine357.05.0
ACE inhibitors
 Enalaprilat183.15.8
 Lisinopril111.76.5
Anticancer drugs
 Methotrexate101.66.2
  • ACE, angiotensin-converting enzyme.

  • 1-a Adapted from Lin, 1995.