CLint and Vmax values for ethoxycoumarin determined in vivo and from scaled microsomal and hepatocyte data
| Study | Vmax | CLint | CLintPrediction |
|---|---|---|---|
| nmol/min/SRW | ml/min/SRW | % | |
| In vivo | 495 | 137 | |
| Microsomal hydroxycoumarin formation | 26 | 1275-a | 93 |
| Microsomal ethoxycoumarin depletion | 53 | 39 | |
| Hepatocyte hydroxycoumarin formation | 17 | 1225-a | 89 |
| Hepatocyte ethoxycoumarin depletion | 117 | 85 |
↵5-a With fm correction (see text).