Table 1

Characteristic fragment ions of paclitaxel metabolites obtained using LC/MS-APCI experiments

CompoundRetention Time (min)Molecular Ion (MH+)Characteristic fragment ions (m/z)
(P1) 10-deacetyl baccatin III5.00545527t, 509t
(P2) baccatin III5.50587527t, 509t
(P3) dihydroxypaclitaxel8.00886868m, 826m, 808m, 602t, 585t, 525t, 463t, 403t, 302s, 284s
(P4)p-hydroxyphenyl C3′ paclitaxel9.20870852m, 810m, 792m, 569t, 551t, 509t, 447t, 387t, 302s, 284s
(P5) 6α-hydroxypaclitaxel15.50870852m, 810m, 792m, 602t, 585t, 525t, 463t, 403t, 286s, 268s
(P6) 10-deacetylpaclitaxel16.40812794m, 776m, 690m, 527t, 509t, 286s, 268s
(P) paclitaxel20.10854836m, 794m, 776m, 569t, 551t, 509t, 447t, 387t, 286s, 268s