Table 2

NMR spectra differences between paclitaxel (P), monohydroxypaclitaxel (P4 and P5) and dihydroxypaclitaxel (P3) metabolites

ProtonP PaclitaxelP5 6α OH PaclitaxelP4p-Hydroxyphenyl-C3′-paclitaxelP3 Dihydroxypaclitaxel
3′a
3′b7.5–7.3  (5H) m7.65–7.35 (5H) m7.17  (2H) d (8)7.36  (2H) d (8)
3′c6.71  (2H) d (8)6.87  (2H) d (8)
5H4.94  (1H) d (9)4.84  (1H) s4.94  (1H) d (9)4.83  (1H) s
6Hα2.54  (1H) m2.54  (1H) m
6Hβ)1.88  (1H) m3.95  (1H) m1.88  (1H) m3.9  (1H) m
7H4.40  (1H) m4.21  (1H) d (9)4.40  (1H) m4.22  (1H) d (9)