Plasma pharmacokinetic parameters and total recovered amounts from the bile and urine
| Compound | Plasma | Bile (% of the dose) | Urine (% of the dose) | ||
|---|---|---|---|---|---|
| AUC (0–51 hr mM hr) | Cmax (μM) | Tmaxmin (postinfusion) | |||
| Paclitaxel (P) | 14.0 | 4.88 | 0 | 0.9 | 2.7 |
| Dihydroxy-P(P3) | 8.4 | 1.37 | 60 | 16.0 | 0.13 |
| p-OH-phenyl-C3′-P (P4) | 3.0 | 0.39 | 15 | 2.8 | 0.02 |
| 6α OH-P (P5) | 2.0 | 0.38 | 15 | 12.9 | 0.09 |
| 10-Deacetyl-P (P6) | 0.2 | 0.08 | 0 | 1.1 | 0.01 |