Plasma protein binding and RB value of tamsulosin in rats, dogs, and humans
| Drug concentrations5-a(ng/ml) | Rats | Dogs | Humans | |
|---|---|---|---|---|
| % bound (fu) | 200 | 80.6 (0.194) | 90.2 (0.098) | 98.9 (0.011) |
| 600 | 79 (0.210) | 90.3 (0.097) | 99.1 (0.009) | |
| RB | 50 | 1.20 | 0.72 | ND |
| 200 | ND | ND | 0.53 |
Values represent the mean of triplicate determinations.
ND, Not determined.
↵5-a Nominal concentration of 14C-tamsulosin in plasma or blood before centrifugation.