Kinetic parameters for ritonavir metabolism by individual liver (LMS) and enterocyte (EMS) microsomes and expressed CYP enzymes
Microsomes | KM | Vmax |
---|---|---|
μM | pmol/min/mg | |
LMS 4 | 0.992-a | 20.32-a |
LMS 9 | 0.852-a | 22.12-a |
LMS 10 | 0.912-a | 17.82-a |
Mean ± SD | 0.92 ± 0.07 | 20.1 ± 2.2 |
EMS 12 | 0.012 | 64.1 |
EMS 13 | 0.099 | 157.1 |
EMS 15 | 0.077 | 46.8 |
Mean ± SD | 0.063 ± 0.045 | 89.4 ± 59.3 |
CYP2D6 | 1.02-a | 0.93a,b |
CYP3A4 | 0.068 | 1.372-b |
CYP3A5 | 0.047 | 1.002-b |