Pharmacokinetic parameters [mean and coefficient of variation (CV)] for total radioactivity after oral or iv administration of 10 mg/kg [14C]meloxicam to male mini-pigs (N = 3)
| Intravenous | Oral | ||||||
|---|---|---|---|---|---|---|---|
| Parameter | Unit | Mean | CV | Parameter | Unit | Mean | CV |
| % | % | ||||||
| C max | mg-eq/liter | 15.35 | 21.8 | ||||
| t max | hr | 3.0 | 57.7 | ||||
| AUC0–∞ | mg-eq·hr/ liter | 243 | 24.9 | AUC0–∞ | mg-eq·hr/ liter | 214 | 14.5 |
| MRTtot | hr | 67.4 | 34.1 | MRTtot | hr | 67.5 | 27.5 |
| t 1/2 | hr | 121 | 12.0 | t 1/2 | hr | 145 | 23.0 |
| V z | liters/kg | 7.38 | 17.8 | V z/F | liters/kg | 9.85 | 23.9 |
| V ss | liters/kg | 2.97 | 47.3 | ||||
| CL | liters/hr/kg | 0.043 | 22.0 | CL/F | liters/hr/kg | 0.047 | 15.5 |