Table 3

Pharmacokinetic parameters for zolpidem and fluoxetine/norfluoxetine in female subjects (N = 29) during coadministration of zolpidem (10 mg) and fluoxetine (20 mg)

TreatmentAUC0–12AUC0–24CmaxTmaxT1/2
ng·hr/ml ng·hr/ml ng/ml hr hr
ZPD
 Day 1 (ZPD only)853.5  ± 55.48934.9  ± 66.04163.52  ± 7.741.81  ± 0.193.11  ± 0.15
 Day 28 (FLU + ZPD)824.1  ± 55.19917.04  ± 69.03167.94  ± 8.921.67  ± 0.243.29  ± 0.15
 Day 32 (FLU + 5 ZPD)878.0  ± 64.04978.77  ± 83.63175.91  ± 9.981.54  ± 0.193.64  ± 0.243-a
FLU
 Day 27 (FLU only)NA3-b 2674.53  ± 226.44133.48  ± 11.098.28  ± 0.82NA
 Day 32 (FLU + 5 ZPD)NA2879.63  ± 229.71142.23  ± 10.859.04  ± 0.9288.12  ± 7.223-c
Norfluoxetine
 Day 27 (FLU only)NA3487.31  ± 158.90165.57  ± 7.596.40  ± 1.02
 Day 32 (FLU + 5 ZPD)NA3674.90  ± 178.62177.44  ± 8.4911.04  ± 1.93

  • ZPD, Zolpidem; FLU, Fluoxetine.

  • ↵3-a Significantly different from days 1 and 28 (p < 0.05).

  • ↵3-b NA, not applicable.

  • ↵3-c N = 24 at day 32.