Kinetic evaluation of delavirdine metabolism by liver microsomes from several species
| Species | Condition | KM(μM) | Vmax (nmol/min/mg) | Vmax/KM (ml/min/mg) |
|---|---|---|---|---|
| Human | Pooled | 6.8 ± 0.8 | 0.44 ± 0.01 | 64 |
| Rat | Male | 9.9 ± 1.0 | 0.40 ± 0.1 | 40 |
| Monkey | Cynomolgus | 4.4 ± 0.6 | 0.60 ± 0.02 | 135 |
| Dog | Beagle | 12.6 ± 1.9 | 0.07 ± 0.01 | 6 |
Initial rate of delavirdine desalkylation was determined.KM and Vmax were estimated by nonlinear curve fitting based on a single experiment using 8–11 substrate concentrations.