Table 3

Metabolite profiles in rat plasma and liver extracts after oral administration of 1 mg/kg cerivastatin3-a

Metabolite (%)3-bSampling Time (hr)
PlasmaLiver
0.5137240.513724
Cerivastatin66.055.621.85.83-c 82.575.559.627.1
M-1 4.94.53.30.94.64.75.63.8
M-21 2.57.915.440.246.21.93.27.632.350.8
M-30 0.31.24.03.41.62.23.57.87.5
Unknown start18.621.645.440.440.24.48.615.115.620.0
  • 3-a Established by TLC; experimental conditions were as described in “Materials and Methods.”

  • 3-b Values are given in % of extract.

  • 3-c Not detected.