Metabolite (%)5-b | Sampling Time (hr) | |||
---|---|---|---|---|
Mouse | Rat | Dog | ||
Male (N = 4) | Male (N = 3) | Female (N = 3) | Female (N = 1) | |
0–7 | 0–24 | 0–48 | ||
Cerivastatin | 0.5 | 7.2 | 8.2 | 22.7 |
M-1 | —5-c | 5.5 | 18.7 | 13.1 |
M-2 | — | — | — | 0.8 |
M-3 | — | — | — | 3.9 |
M-4 | — | — | — | 0.8 |
M-5 | — | — | — | 5.2 |
M-6 | — | — | — | 0.6 |
M-7 | — | — | — | 0.4 |
M-8 | — | 1.8 | 1.5 | 18.0 |
M-9 | — | — | — | 1.1 |
M-15 | 4.9 | 13.7 | 12.2 | — |
M-16 | 7.8 | 19.4 | 8.8 | — |
M-18 | 3.8 | 11.8 | 5.6 | — |
M-19 | 13.2 | 15.8 | 5.2 | — |
M-20 | 3.2 | — | — | — |
M-22 | — | — | — | 0.9 |
M-25 | 15.0 | — | — | — |
M-26 | 8.3 | — | — | — |
M-27 | 2.8 | — | — | — |
M-28 | 2.1 | — | — | — |