Table 6

Metabolites excreted in mouse, rat, and dog urine after oral administration of [14C]cerivastatin6-a

Metabolite (%)6-bDose and Sampling Time
Mouse [Male (N = 3)] 2 mg/kg; 0–7 hr Rat [Male (N = 5)] 20 mg/kg; 0–7 hrDog [Female (N = 1)] 2 mg/kg; 0–24 hr
Cerivastatin0.030.010.3
M-1 —6-c 0.80.9
M-2 — —0.1
M-3/M-6 — —0.1
M-4 — —0.6
M-5 — —0.7
M-8 — 0.020.07
M-15 0.70.06—
M-16 0.90.04—
M-18 0.1——
M-22 — 0.06—
M-25 0.4——
M-26 0.1——

  • ↵6-a Established by HPLC; experimental conditions were as described in “Materials and Methods.”

  • ↵6-b Values are given in % of dose.

  • ↵6-c Not detected.