Reactivity of rabbit and human UGTs with primary and secondary amines
| Rabbit/Human UGT | Primary Amines | Secondary Amines | Reference |
|---|---|---|---|
| Purified enzymes | |||
| Rabbit | |||
| Estrone UGT | αNA ≈ βNA ≈ 4-ABP | NT | (Tephly et al., 1988) |
| Human | |||
| pI 6.2 UGT | αNA | NT | (Irshaid and Tephly, 1987) |
| pI 7.4 UGT | αNA > 4-ABP > βNA | NT | (Irshaid and Tephly, 1987) |
| Expressed UGTs | |||
| Human | |||
| UGT2B15 | None | NT | (Green et al., 1994) |
| UGT1A1 | None | NT | (King et al., 1996) |
| UGT1A3 | 4-ABP > αNA ≈ 2-ABP ≈ βNA | Diphenyl amine | (Green et al., 1998) |
| UGT1A4 | αNA, βNA, 4-ABP, 2-ABP > benzidine >> dapsone | Diphenyl amine Desmethyl clozapine | (Green et al., 1995; Green and Tephly, 1996) |
| UGT1A6 | αNA > βNA >> 4ABP | N-OH βNA >> N-OH 4-ABP | (Huskey et al., 1994; |
| Triazoles and tetrazoles | Orzechowski et al., 1994) | ||
| UGT1A9 | αNA > βNA > 4-ABP Dapsone | N-OH βNA >> N-OH 4-ABP | (Orzechowski et al., 1994) |
NT indicates that these compounds were not tested.