1H-NMR chemical shifts and coupling constants of telmisartan 1-O-acylglucuronide and isomeric acylglucuronides
| Isomers | δ in ppm J in Hz | ||||
|---|---|---|---|---|---|
| H1′ | H2′ | H3′ | H4′ | H5′ | |
| 1-O-acyl(β) | 6.44 d | 4.21 t | 4.36 t | 4.60 t | 4.72 d |
| J∼8.1 | J∼8.3 + 8.8 | J∼8.9 + 9.0 | J∼9.2 + 9.5 | J∼9.7 | |
| 2-O-acyl(α) | 6.13 d | 5.56 dd | 5.02 t | 4.69 t | 5.37 d |
| J∼3.5 | J∼3.5 + 9 | J∼9.7 | J∼9.8 | J∼9.8 | |
| 2-O-acyl(β) | 5.39 d | 5.74 t | 4.35 t | 4.56 t | 4.60 d |
| J∼8 | J∼8 + 9 | J∼9 | J∼9 | J∼9 | |
| 3-O-acyl(α) | 5.93 d | 4.25 dd | 6.33 t | 4.56 t | 5.35 d |
| J∼3.3 | J∼3.3 + 9.9 | J∼9.4 + 9.6 | J∼9.7 | J∼9.8 | |
| 3-O-acyl(β) | 5.41 d | 4.18 dd | 6.00 t | 4.54 t | 4.69 d |
| J∼7.7 | J∼7.9 + 9.4 | J∼9.6 | J∼9.7 | J∼9.8 | |
| 4-O-acyl(α) | 6.02 d | 4.27 dd | 1-a4.81 t | 1-a5.95 t | 5.28 d |
| J∼4 | J∼4 + 10 | J∼9 | J∼10 | J∼10 | |
| 4-O-acyl(β) | 5.44 d | Si | 1-a4.43 t | 1-a5.93 t | 4.71 d |
| J∼8 | J∼9 | J∼9 | J∼10 | ||
Resonances of the glucuronic acid moieties are listed. s = singulet, d = duplet, dd = double duplet, t = triplet, si = superimposed.
↵1-a Arbitrary.