Pharmacokinetic parameters of telmisartan 1-O-acylglucuronide after i.v. dosing of 4.02 mg/kg to rats (n = 6)
| Parameter | Unit | CV | |
|---|---|---|---|
| % | |||
| MRTtot | h | 0.05 | 6.9 |
| V c | liters/kg | 0.27 | 20.3 |
| V ss | liters/kg | 0.46 | 25.6 |
| CL | ml/min/kg | 180 | 19.3 |
| C(0) | μg/ml | 15.5 | 23.5 |
| AUCmodel | μg · h/ml | 0.38 | 18.4 |
| C max | μg/ml | 15.5 | 23.5 |
Pharmacokinetic parameters were calculated for individual animals using a two-compartment disposition model.
Pharmacokinetic parameters: Vc, the apparent volume of distribution of the central compartment after intravascular dosing; Vss, the apparent volume of distribution at steady state; MRT, mean residence time; CL, total body clearance from plasma after intravascular dosing; AUCmodel, area under the fitted curve from zero time to infinity; C(0), the back-extrapolated plasma concentration after i.v. bolus injection.