Table 2

Pharmacokinetic parameters defining systemic disposition of SB-265123 in various species after i.v. and oral administration

ParameterRatBDC RatDogMouseMonkey
i.v. C max(ng/ml)2-a 1780  ± 5851180, 1310582  ± 87880  ± 2651863  ± 80
T 1/2α(min)24.1  ± 19.413.6, 16.211.2  ± 3.61.87  ± 0.789.65  ± 3.34
T 1/2β(min)192  ± 7982.2, 103559  ± 11026.3  ± 7.8554  ± 779
MRT (min)2-a 200  ± 5094.6, 63.0396  ± 12228.0  ± 15.6241  ± 338
CL (kg · ml/min)2-a 4.05  ± 2.008.19, 11.215.2  ± 2.375.3  ± 19.213.2  ± 2.0
VdSS (ml/kg)2-a 807  ± 477774, 7086030  ± 23002040  ± 10552742  ± 3605
k a (min−1)2-a 0.051  ± 0.0400.55, 0.130.71  ± 0.080.35  ± 0.330.043  ± 0.014
Oral T max(min)57.5  ± 38.310.5, 17.19.90  ± 0.6412.9  ± 11.732.7  ± 6.2
Oral C max(ng/ml)2-a 2980  ± 7001190, 1080265  ± 45503  ± 124662  ± 282
Oral F (%)2-a 118  ± 36122, 14043.5  ± 11.468.6  ± 32.024.0  ± 6.3

Data are presented as means ± S.D.

  • 2-a Parameter significantly different across species, one-way ANOVA.