Table 4

Plasma protein binding of SB-265123 in mouse, rat, dog, monkey, and human

ConcentrationSB-265123 Unbound in Plasma
MouseRatDogMonkeyHuman
%
1000 ng/ml4-a 2.02  ± 0.601.07  ± 0.051.05  ± 0.050.82  ± 0.100.43  ± 0.03
10,000 ng/ml4-a 0.64  ± 0.064-b 1.41  ± 0.104-b 1.30  ± 0.074-b 0.94  ± 0.030.60  ± 0.024-b
All data combined1.33  ± 0.841.24  ± 0.201.18  ± 0.150.88  ± 0.090.52  ± 0.09

Data are presented as means ± S.D. for N = 3 determinations, corrected for nonspecific binding to the ultrafiltration device.

  • 4-a Statistically different across species, one-way ANOVA,p < .05.

  • 4-b Statistically different between concentrations, two-tailed Student’s t test, p < .05.