Table 1

Intrinsic clearance for R (+)- and S (−)-gallopamil in nine different human liver microsomes

Human Liver MicrosomesCLint
R(+)S (−)S/R ratio
ml/min/mg protein
HL-310.3070.2320.76
HL-320.2120.1730.82
HL-330.5180.3870.75
HL-340.4420.2740.62
HL-350.1400.0920.66
HL-370.1130.0510.45
HL-380.5810.3140.54
HL-390.2350.1490.63
HL-400.3280.1700.52
Mean0.3200.2051-150 0.64
S.D.0.1650.1070.12
  • 1-150p < .01.