Table 2

Correlations between the intrinsic clearance of gallopamil enantiomers and metabolic activities (V_max/K_m) of seven selective substrates of distinct human CYP isoforms

Enzyme Activity	P-450	Correlation Coefficients R (+) S (−)
PhenacetinO-deethylation	1A2	0.250	0.453
Coumarin 7-hydroxylation	2A6	0.622	0.518
Diclofenac 4′-hydroxylation	2C9	0.153	0.450
S-Mephenytoin 4′-hydroxylation	2C19	0.769^2-150	0.571
Desipramine 2-hydroxylation	2D6	0.545	0.456
Chlorzoxazone 6-hydroxylation	2E1	0.170	0.279
Testosterone 6β-hydroxylation	3A4	0.977^**	0.900^**

↵2-150 p < .05, ** p < .001.