Pharmacokinetic parameters for whole blood, liver, lungs, and kidneys after oral administration of [14C]PEITC and [14C]PHITC
| Organ | [14C]PEITC | [14C]PHITC | ||||
|---|---|---|---|---|---|---|
| Parameter1-a | Estimate | S.E. | Parameter | Estimate | S.E. | |
| Blood | AUC1-a | 328.1 | 106.93 | AUC | 296.14 | 37.07 |
| T1/2a (h) | 1.34 | 3.15 | T1/2a(h) | 2.63 | 0.63 | |
| T1/2α, T1/2β(h) | 2.41, 21.7 | 6.95, 25.77 | T1/2e(h) | 20.47 | 4.74 | |
| Tmax(h) | 2.94 | 0.78 | Tmax (h) | 8.93 | 0.96 | |
| Cmax (pmol/μl) | 18.77 | 2.90 | Cmax(pmol/μl) | 7.41 | 0.46 | |
| Liver | AUC | 1277.57 | 291.76 | AUC | 3406.62 | 337.31 |
| T1/2a (h) | 0.44 | 0.14 | T1/2a(h) | 2.72 | 0.60 | |
| T1/2e(h) | 20.45 | 5.84 | T1/2e (h) | 15.49 | 3.11 | |
| Tmax (h) | 2.50 | 0.56 | Tmax(h) | 8.28 | 0.74 | |
| Cmax(pmol/mg) | 39.79 | 3.29 | Cmax (pmol/mg) | 105.26 | 5.51 | |
| Lungs | AUC | 346.32 | 6.51 | AUC | 885.45 | 105.34 |
| T1/2a (h) | 0.97 | 0.14 | T1/2a(h) | 2.38 | 0.30 | |
| T1/2e(h) | 21.30 | 2.99 | T1/2e (h) | 46.90 | 8.01 | |
| Tmax (h) | 4.53 | 0.40 | Tmax(h) | 10.79 | 0.66 | |
| Cmax(pmol/mg) | 9.73 | 0.39 | Cmax (pmol/mg) | 11.16 | 0.40 | |
| Kidneys | AUC | 987.94 | 114.88 | AUC | 1264.92 | 30.97 |
| T1/2a (h) | 1.18 | 0.20 | T1/2a(h) | 2.33 | 0.60 | |
| T1/2e(h) | 11.37 | 1.99 | T1/2e (h) | 42.55 | 14.31 | |
| Tmax (h) | 4.31 | 0.39 | Tmax(h) | 10.36 | 1.31 | |
| Cmax(pmol/mg) | 46.29 | 2.06 | Cmax(pmol/mg) | 17.41 | 1.30 | |
T1/2α, α half-life of elimination (two compartment), T1/2β, β half-life of elimination (two compartment).
↵1-a Units of AUC are picomoles per milligram × hours (nanomoles per milliliter times hour for whole blood).