Table 1

Sample processing and HPLC-MS conditions for 29 drugs used in this analysis

Drug	Internal Standard	Incubation Termination	Mobile Phase System	CH₃CN	MS Polarity	m/z	R_t
				%			min
Basic compounds
Chlorpromazine	Amitriptyline	NaOH	1	36.5	+	318.8	1.2
Propafenone	Verapamil	NaOH	1	32.0	+	341.9	1.4
Verapamil	Propafenone	NaOH	1	32.0	+	455.1	1.6
Diphenhydramine	Propafenone	NaOH	1	32.0	+	256.0	0.8
Lorcainide	Propafenone	NaOH	1	32.0	+	371.0	1.4
Diltiazem	Propafenone	NaOH	1	32.0	+	415.0	1.0
Amitriptyline	Imipramine	NaOH	1	36.5	+	278.0	1.0
Desipramine	Amitriptyline	NaOH	1	36.5	+	266.5	0.8
Imipramine	Amitriptyline	NaOH	1	36.5	+	281.0	1.0
Ketamine	Metoprolol	NaOH	1	18.5	+	237.8	0.8
Quinidine	Ondansetron	NaOH	1	18.5	+	325.0	1.5
Clozapine	Diltiazem	NaOH	1	27.5	+	326.9	1.2
Neutral compounds
Dexamethasone	Prednisone	NaOH	1	32.0	+	393.1	1.8
Prednisone	Dexamethasone	NaOH	1	32.0	+	359.1	1.1
Diazepam	Midazolam	NaOH	1	50.0	+	284.9	1.4
Midazolam	Diazepam	NaOH	1	50.0	+	325.8	0.8
Methoxsalen	Diazepam	CH₃CN	1	50.0	+	217.0	1.0
Alprazolam	Triazolam	NaOH	1	41.0	+	309.0	0.9
Triazolam	Alprazolam	NaOH	1	41.0	+	342.9	1.0
Zolpidem	Quinine	NaOH	1	23.0	+	308.0	1.5
Acidic compounds
Diclofenac	Ibuprofen	HCl	2	32.0	−	294.0	1.1
Ibuprofen	Diclofenac	HCl	2	32.0	−	205.1	1.3
Tolbutamide	Warfarin	HCl	2	27.5	−	269.0	1.2
Warfarin	Tolbutamide	HCl	2	27.5	−	307.3	1.2
Tenidap	Warfarin	HCl	2	32.0	−	319.1	1.3
Tenoxicam	Piroxicam	HCl	2	27.5	−	336.1	0.8
Amobarbital	Methohexital	HCl	2	45.5	−	225.2	0.8
Hexobarbital	Methohexital	HCl	2	45.5	−	235.1	0.8
Methohexital	Amobarbital	HCl	2	45.5	−	261.1	1.5