Sample processing and HPLC-MS conditions for 29 drugs used in this analysis
Drug | Internal Standard | Incubation Termination | Mobile Phase System | CH3CN | MS Polarity | m/z | Rt |
---|---|---|---|---|---|---|---|
% | min | ||||||
Basic compounds | |||||||
Chlorpromazine | Amitriptyline | NaOH | 1 | 36.5 | + | 318.8 | 1.2 |
Propafenone | Verapamil | NaOH | 1 | 32.0 | + | 341.9 | 1.4 |
Verapamil | Propafenone | NaOH | 1 | 32.0 | + | 455.1 | 1.6 |
Diphenhydramine | Propafenone | NaOH | 1 | 32.0 | + | 256.0 | 0.8 |
Lorcainide | Propafenone | NaOH | 1 | 32.0 | + | 371.0 | 1.4 |
Diltiazem | Propafenone | NaOH | 1 | 32.0 | + | 415.0 | 1.0 |
Amitriptyline | Imipramine | NaOH | 1 | 36.5 | + | 278.0 | 1.0 |
Desipramine | Amitriptyline | NaOH | 1 | 36.5 | + | 266.5 | 0.8 |
Imipramine | Amitriptyline | NaOH | 1 | 36.5 | + | 281.0 | 1.0 |
Ketamine | Metoprolol | NaOH | 1 | 18.5 | + | 237.8 | 0.8 |
Quinidine | Ondansetron | NaOH | 1 | 18.5 | + | 325.0 | 1.5 |
Clozapine | Diltiazem | NaOH | 1 | 27.5 | + | 326.9 | 1.2 |
Neutral compounds | |||||||
Dexamethasone | Prednisone | NaOH | 1 | 32.0 | + | 393.1 | 1.8 |
Prednisone | Dexamethasone | NaOH | 1 | 32.0 | + | 359.1 | 1.1 |
Diazepam | Midazolam | NaOH | 1 | 50.0 | + | 284.9 | 1.4 |
Midazolam | Diazepam | NaOH | 1 | 50.0 | + | 325.8 | 0.8 |
Methoxsalen | Diazepam | CH3CN | 1 | 50.0 | + | 217.0 | 1.0 |
Alprazolam | Triazolam | NaOH | 1 | 41.0 | + | 309.0 | 0.9 |
Triazolam | Alprazolam | NaOH | 1 | 41.0 | + | 342.9 | 1.0 |
Zolpidem | Quinine | NaOH | 1 | 23.0 | + | 308.0 | 1.5 |
Acidic compounds | |||||||
Diclofenac | Ibuprofen | HCl | 2 | 32.0 | − | 294.0 | 1.1 |
Ibuprofen | Diclofenac | HCl | 2 | 32.0 | − | 205.1 | 1.3 |
Tolbutamide | Warfarin | HCl | 2 | 27.5 | − | 269.0 | 1.2 |
Warfarin | Tolbutamide | HCl | 2 | 27.5 | − | 307.3 | 1.2 |
Tenidap | Warfarin | HCl | 2 | 32.0 | − | 319.1 | 1.3 |
Tenoxicam | Piroxicam | HCl | 2 | 27.5 | − | 336.1 | 0.8 |
Amobarbital | Methohexital | HCl | 2 | 45.5 | − | 225.2 | 0.8 |
Hexobarbital | Methohexital | HCl | 2 | 45.5 | − | 235.1 | 0.8 |
Methohexital | Amobarbital | HCl | 2 | 45.5 | − | 261.1 | 1.5 |