Table 4

Summary of human clearance values predicted from in vitro intrinsic clearance, protein binding, and microsome binding values using well-stirred and parallel-tube models of hepatic extraction

Drug	Actual Human CL_blood			Predicted Human CL_blood^a
		Well-Stirred		Parallel-Tube
		No Binding (eq. 1)	f_u(bl) Only (eq. 2)	f_u(bl)and f_u(mic) (eq. 3)	No binding (eq. 4)	f_u(bl)Only (eq. 5)	f_u(bl) and f_u(mic) (eq. 6)
	mL/min/kg
Basic compounds
Chlorpromazine	11	11	1.5	8.6	15	1.5	11
Propafenone	19	19	6.5	13	21	7.6	17
Verapamil	19	18	9.0	13	21	11	17
Diphenhydramine	9.5	1.9	0.7	2.2	2.0	0.7	2.3
Lorcainide	18	15	6.7	9.9	19	7.8	12
Diltiazem	12	8.7	2.9	3.6	11	3.0	3.9
Amitriptyline	12	8.2	0.8	4.2	10	0.8	4.6
Desipramine	12	9.4	2.8	8.8	12	2.9	11
Imipramine	12	10	1.6	6.6	12	1.6	7.7
Ketamine	20	12	12	15	15	15	20
Quinidine	2.7	2.9	0.5	1.4	3.1	0.5	1.4
Clozapine	2.9	3.8	0.3	1.9	4.1	0.3	1.9
Neutral compounds
Dexamethasone	3.8	2.6	1.0	1.0	2.8	1.0	1.0
Prednisone	4.9	2.4	0.8	3.4	2.5	0.8	3.6
Diazepam	0.6	2.1	0.04	0.2	2.2	0.04	0.2
Midazolam	8.7	19	8.8	9.4	21	11	12
Methoxsalen	18	14	4.3	4.5	18	4.7	5.0
Alprazolam	0.76	1.5	0.64	0.95	1.5	0.64	0.97
Triazolam	4.7	10	2.7	3.3	12	2.8	3.6
Zolpidem	5.7	2.5	0.3	0.5	2.6	0.3	0.5
Acidic compounds
Diclofenac	7.6	19	1.6	1.6	21	1.6	1.6
Ibuprofen	1.5	6.2	0.2	0.2	7.2	0.2	0.2
Tolbutamide	0.36	0.86	0.07	0.07	0.88	0.07	0.07
Warfarin	0.08	0.46	0.01	0.02	0.46	0.01	0.02
Tenidap	0.10	5.9	0.01	0.03	6.8	0.01	0.03
Tenoxicam	0.03	1.6	0.02	0.03	1.6	0.02	0.03
Amobarbital	0.35	0.90	0.24	0.32	0.92	0.24	0.32
Hexobarbital	3.6	2.1	1.2	1.40	2.2	1.2	1.45
Methohexital	16	15	9.9	11	19	12	14

Equations used are as follows: Equation 1 Equation 2 Equation 3 Equation 4 Equation 5 Equation 6^a A value of 21 ml/min/kg was used for human hepatic blood flow (Q).