Table 4

Mean (SD) concentrations of total radioactivity in tissues after administration of a 5 mg/kg oral dose of [4-¹⁴C] stavudine to male rats (N = 3/gender)

Tissue	Mean (SD) Tissue Concentrations at Various Times (μg-eq/g)
Tissue	0.5 h	3 h	6 h	24 h	48 h
Adrenal Gland	2.72 (0.70)	0.20 (0.10)	0.07 (0.04)	0.01 (0.00)	0.02 (0.00)
Aqueous Humor	0.87 (0.18)	0.30 (0.02)	0.05 (0.01)	0^4-c	0
Blood^4-a	2.61 (0.14)	0.18 (0.02)	0.03 (0.00)	0.01 (0.00)	0.01 (0.00)
Bone	0.16 (0.06)	0.07 (0.01)	0.02 (0.00)	0	0
Bone Marrow	2.42 (0.17)	0.26 (0.01)	0.06 (0.01)	0.02 (0.00)	0.02 (0.00)
Brain	0.30 (0.08)	0.12 (0.01)	0.04 (0.00)	0	0
CSF^4-a	0.55 (0.12)	0.11 (0.04)	0.02 (0.00)	0	0
Eyes	0.98 (0.25)	0.08 (0.14)	0.06 (0.01)	0.04 (0.03)	0.01 (0.00)
Fat	1.83 (1.65)	0.13 (0.00)	0.06 (0.07)	0	0
Heart	3.07 (0.97)	0.17 (0.04)	0.03 (0.00)	0	0
Kidney	10.6 (1.91)	1.16 (0.82)	0.11 (0.02)	0.01 (0.00)	0.01 (0.00)
Large Intestine	2.47 (0.35)	0.49 (0.12)	1.49 (0.09)	0.06 (0.01)	0.03 (0.00)
Liver	5.31 (2.03)	0.29 (0.04)	0.09 (0.01)	0.04 (0.02)	0.04 (0.01)
Lung	2.99 (0.95)	0.20 (0.03)	0.03 (0.01)	0.01 (0.00)	0.01 (0.00)
Lymph Nodes	2.13 (0.28)	0.16 (0.04)	0.03 (0.01)	0.01 (0.01)	0.01 (0.00)
Ovaries^4-b	2.55 (0.56)	0.21 (0.07)	0.04 (0.01)	0.01 (0.00)	0
Pancreas	3.89 (2.21)	0.27 (0.09)	0.11 (0.07)	0.01 (0.00)	0.01 (0.00)
Pituitary Gland	4.19 (1.43)	0.15 (0.04)	0.04 (0.01)	0.01 (0.00)	0.01 (0.00)
Plasma^4-a	3.18 (0.15)	0.22 (0.03)	0.05 (0.01)	0.01 (0.00)	0.01 (0.00)
Salivary Gland	2.56 (0.46)	0.22 (0.04)	0.07 (0.01)	0.01 (0.00)	0.01 (0.00)
Skeletal Muscle	1.91 (0.42)	0.29 (0.13)	0.03 (0.02)	0	0
Skin	2.06 (0.23)	0.18 (0.04)	0.03 (0.01)	0.01 (0.00)	0.01 (0.00)
Small Intestine	14.5 (2.03)	1.16 (0.00)	0.18 (0.06)	0.02 (0.01)	0.01 (0.00)
Spleen	2.55 (0.19)	0.19 (0.04)	0.05 (0.02)	0.01 (0.00)	0.01 (0.00)
Stomach	26.3 (22.1)	0.41 (0.17)	0.11 (0.02)	0.01 (0.00)	0.01 (0.00)
Testes	0.78 (0.13)	0.55 (0.08)	0.12 (0.02)	0.01 (0.00)	0.01 (0.00)
Thymus	2.42 (0.35)	0.21 (0.06)	0.04 (0.01)	0.02 (0.01)	0.02 (0.00)
Thyroid	2.80 (1.07)	0.18 (0.03)	0.04 (0.01)	0	0
Tongue	2.56 (0.49)	0.20 (0.02)	0.05 (0.01)	0.01 (0.00)	0.01 (0.00)
Trachea	2.00 (0.31)	0.18 (0.08)	0.03 (0.01)	0.01 (0.00)]	0.01 (0.00)
Urinary Bladder	20.0 (11.7)	31.3 (25.8)	1.95 (2.58)	0.01 (0.00)]	0.01 (0.00)
Uterus^4-b	3.00 (0.43)	0.21 (0.10)	0.03 (0.01)	0.01 (0.00)	0
Vena Cava	3.92 (1.90)	0.82 (0.71)	0.11 (0.11)	0	0

↵4-a Concentrations are expressed as μg-eq/ml.
↵4-b In females only.
↵4-c Not detectable; counts were <60 dpm/sample and counting error was >20%.