Pharmacokinetic parameters for stavudine after oral administration in various laboratory animals (N = 3 to 6)
| Species | Dose | Mean (SD) Pharmacokinetic Parameter Value2-a | ||||||
|---|---|---|---|---|---|---|---|---|
| Cmax | Tmax | AUC0–∞ | T1/2 | CLR | UR | F | ||
| (mg/kg) | μg/ml | (h) | (μg · hr/ml) | (h) | (ml/min/kg) | (%) | (%) | |
| Mouse2-b | 25 | 23.0 | 0.08 | ND | 0.30 | ND | ND | 98 |
| Rat | 50 | 30.9 (1.79) | 0.50 (0.25, 0.50) | 33.5 (3.51) | 0.56 (0.08) | 21.0 (2.54)2-e | 82.4 (2.8) | 102 |
| 150 | 166 (73.6) | 0.50 (0.25, 0.50) | 155 (37.3) | 0.67 (0.09) | 12.0 (3.98) | 72.6 (13.3) | ND | |
| 600 | 336 (31.4) | 1.00 (1.00, 1.00)2-c | 739 (95.9) | 1.23 (0.86) | 12.0 (2.13) | 84.8 (6.7) | ND | |
| Monkey | 30 | 16.1 (4.93) | 1.00 (0.50, 2.00) | 27.0 (7.50) | 0.69 (0.06) | ND | ND | 77 |
| 100 | 77.3 (18.0) | 0.50 (0.50, 2.00) | 121 (17.9) | 0.70 (0.07) | ND | ND | ND | |
| 300 | 207 (64.8) | 1.00 (1.00, 2.00) | 554 (148) | 1.10 (0.30)2-d | ND | ND | ND | |
↵2-a Cmax, peak concentration in plasma; Tmax, time at which Cmax occurred; AUC0–∞, area under the plasma concentration-time curve extrapolated to infinity; T1/2, terminal half-life; CLR, renal clearance; UR, urinary recovery of unchanged drug; F, oral bioavailability; ND, not determined; median (minimum, maximum) values reported for Tmax.
↵2-b Data from reference Russell et al., 1990, using a composite curve, N = 3 animals/time point.
↵2-c Statistically different from the 50 and 150 mg/kg dose groups, p < .05.
↵2-d Statistically different from the 30 and 100 mg/kg dose groups, p < .05.
↵2-e Statistically different from the 150 and 600 mg/kg dose groups, p < .05.