Mean (SD) cumulative urinary recovery of unchanged stavudine and total radioactivity following administration of a 50 mg/kg dose of [2-14C] stavudine to male rats (N = 5) and 25 mg/kg dose of [4-14C] stavudine to female monkeys (N = 3)
| Route3-a | Time Interval | Mean (SD) Cumulative Urinary Recovery (% of Dose) | |||
|---|---|---|---|---|---|
| Rat | Monkey3-b | ||||
| Unchanged stavudine | Total radioactivity | Unchanged stavudine | Total radioactivity | ||
| i.v. | 0–24 | 86.8 (2.7) | 84.1 (2.8) | 43.9 (6.3) | 49.5 (5.0) |
| 0–48 | 87.9 (3.1) | 85.2 (2.9) | 44.4 (6.6) | 50.3 (5.4) | |
| 0–72 | 88.2 (3.1) | 85.6 (2.9) | 44.4 (6.6) | 50.4 (5.3) | |
| 0–96 | 88.2 (3.1) | 85.7 (3.0) | 44.4 (6.6) | 50.5 (5.4) | |
| p.o. | 0–24 | 85.0 (3.6) | 83.0 (3.7) | 36.9 (5.8) | 37.9 (1.5) |
| 0–48 | 86.1 (3.1) | 84.1 (3.1) | 37.4 (5.8) | 39.6 (3.1) | |
| 0–72 | 86.4 (2.8) | 84.5 (2.9) | 37.4 (5.8) | 39.8 (3.1) | |
| 0–96 | 86.5 (2.7) | 84.7 (2.7) | 37.4 (5.8) | 39.8 (3.1) | |