Species differences in methionine S-oxidase activity
| Mouse | Dog | Rat | Human | Rabbit | |
|---|---|---|---|---|---|
| Male liver | 1.0 ± 0.1a | 1.3 ± 0.2a,b | 2.2 ± 0.4b | 2.2 ± 0.6b | 3.3 ± 1.0c |
| Female liver | 2.8 ± 0.4 | 2.2 ± 0.5 | 1.7 ± 0.2 | 2.2 ± 0.7 | 3.2 ± 0.9 |
| Dog | Mouse | Rabbit | Rat | |
|---|---|---|---|---|
| Male kidney | 0.3 ± 0.1d | 0.6 ± 0.1d,e | 1.0 ± 0.4e | 2.0 ± 0.3f |
| Female kidney | 0.4 ± 0.0g | 0.7 ± 0.2g,h | 0.8 ± 0.2h | 1.5 ± 0.3i |
Methionine (10 mM) was incubated with liver or kidney microsomes and NADPH-dependent methionine sulfoxide formation was measured by HPLC. Data are presented as means ± S.D. of specific activity (nmol sulfoxide/mg protein · min). Species comparisons (same tissue/sex) were made using one-way ANOVA (α = 0.05), followed by least-significant difference analysis. Data with the same superscript are not significantly different (p < .05).