Microsomes1-a | NVP Metabolite | |||||||
---|---|---|---|---|---|---|---|---|
2-HydroxyNVP | 3-HydroxyNVP | 8-HydroxyNVP | 12-HydroxyNVP | |||||
25 μM | 100 μM | 25 μM | 100 μM | 25 μM | 100 μM | 25 μM | 100 μM | |
2 | 2.99 | 16.23 | 0.46 | 2.74 | 0.09 | 1.79 | 1.71 | 9.24 |
3 | 0.32 | 2.01 | 0.13 | 1.09 | ND | 0.22 | 0.37 | 1.62 |
5 | 0.17 | 1.95 | 0.30 | 0.74 | ND | 0.24 | 0.38 | 1.78 |
6 | 4.15 | 22.66 | 2.50 | 7.09 | 0.45 | 3.06 | 2.71 | 13.59 |
7 | 0.66 | 3.88 | 0.11 | 1.34 | ND | 0.53 | 0.86 | 3.61 |
9 | 0.69 | 2.99 | 1.12 | 2.79 | 0.22 | 0.65 | 0.56 | 2.23 |
10 | 0.47 | 1.33 | ND | 0.35 | ND | 0.17 | 0.44 | 1.73 |
11 | 2.78 | 10.60 | 3.69 | 9.03 | 0.43 | 2.75 | 1.93 | 7.61 |
12 | 0.92 | 1.69 | 0.16 | 0.77 | ND | 0.25 | 0.33 | 1.45 |
13 | 1.57 | 5.37 | 0.45 | 0.98 | 0.14 | 0.59 | 0.90 | 3.46 |
Mean ± S.D.1-b | 1.47 ± 1.37 | 6.87 ± 7.32 | 0.99 ± 1.27 | 2.69 ± 2.98 | 0.26 ± 0.17 | 1.03 ± 1.10 | 1.02 ± 0.82 | 4.63 ± 4.14 |