Table 2

The in vitro CYP-specific enzyme activities (picomoles per minute per milligram of microsomal protein) of the characterized human hepatic microsomes used in the NVP hydroxylation assays

Specific Activity^2-b	Microsomes^2-a
Specific Activity^2-b	2	3	5	6	7	9	10	11	12	13
EROD	43.5	47.7	28.1	9.92	40.4	26.2	14.0	95.3	11.3	31.7
CNDM	70	53	47	15	68	34	7	189	7	38
CH	199	784	972	1080	710	120	230	958	271	249
EFCOD	124	75	63	227	55	100	ND	312	40	57
MND	103	54	54	258	67	100	53	291	45	55
TMH	275	106	133	226	187	118	151	120	103	158
MPH	15	65	52	78	113	28	7	22	34	37
DODM	109	27	281	<5	58	144	74	231	182	176
CZH	6860	1630	2560	2960	1970	3980	2300	1710	1450	1910
TSTH	10100	1250	1140	12500	2430	2040	1000	6390	861	3260
LAH	890	770	840	1100	770	740	480	530	310	790

ND = Not detected
↵2-a Microsome identification number provided by Human Biologics, Inc. (Phoenix, AZ).
↵2-b EROD = 7-Ethoxyresorufin-O-deethylase (CYP1A)
CNDM = Caffeine N-demethylase (CYP1A2)
CH = Coumarin 7-hydroxylase (CYP2A6)
EFCOD = furafylline-inhibited 7-ethoxy-4-trifluoromethyl coumarin-O-deethylase (CYP2B6)
MND = S-Mephenytoin N-demethylase (CYP2B6)
TMH = Tolbutamide methyl-hydroxylase (CYP 2C9)
MPH = S-Mephenytoin 4-hydroxylase (CYP2C19)
DODM = Dextromethorphan O-demethylase (CYP2D6)
CZH = Chlorzoxazone 6-hydroxylase (CYP2E1)
TSTH = Testosterone 6β-hydroxylase (CYP3A4)
LAH = Lauric acid 12-hydroxylase (CYP4A)