Table 3

The coefficients of determination (r²) for the in vitro rates of CYP-specific enzyme activities versus in vitro rates of nevirapine metabolite formation by characterized human hepatic microsomes in incubations with 25 or 100 μM NVP

Specific Activity^3-b	NVP Metabolite^3-a
	2-HydroxyNVP		3-HydroxyNVP		8-HydroxyNVP		12-HydroxyNVP
	25 μM	100 μM	25 μM	100 μM	25 μM	100 μM	25 μM	100 μM
EROD	0.032	0.007	0.253	0.283	0.047	0.141	0.064	0.020
CNDM	0.079	0.034	0.381	0.407	0.107	0.239	0.132	0.061
CH	0.073	0.110	0.214	0.268	0.873	0.206	0.182	0.151
EFCOD	0.592	0.456	0.944	0.980	0.742	0.848	0.679	0.531
MND	0.643	0.546	0.947	0.988	0.877	0.895	0.752	0.623
TMH	0.418	0.566	0.001	0.033	0.078	0.240	0.410	0.527
MPH	0.002	0.006	0.045	0.000	0.326	0.000	0.010	0.012
DODM	0.046	0.104	0.007	0.000	0.025	0.017	0.064	0.100
CZH	0.149	0.236	0.005	0.004	0.351	0.078	0.106	0.182
TSTH	0.933	0.994	0.322	0.500	0.126	0.821	0.919	0.978
LAH	0.196	0.379	0.002	0.048	0.000	0.163	0.273	0.346

↵3-a Bold numbers indicate the best correlations.
↵3-b EROD = 7-Ethoxyresorufin-O-deethylase (CYP1A)
CNDM = Caffeine N-demethylase (CYP1A2)
CH = Coumarin 7-hydroxylase (CYP2A6)
EFCOD = furafylline-inhibited 7-ethoxy-4-trifluoromethyl coumarin-O-deethylase (CYP2B6)
MND = S-Mephenytoin N-demethylase (CYP2B6)
TMH = Tolbutamide methyl-hydroxylase (CYP 2C9)
MPH = S-Mephenytoin 4-hydroxylase (CYP2C19)
DODM = Dextromethorphan O-demethylase (CYP2D6)
CZH = Chlorzoxazone 6-hydroxylase (CYP2E1)
TSTH = Testosterone 6β-hydroxylase (CYP3A4)
LAH = Lauric acid 12-hydroxylase (CYP4A)
n = 10, except for 3-hydroxynevirapine (25 μM), wheren = 9, and 8-hydroxynevirapine (25 μM), wheren = 5