Table 2

Kinetic parameters of furosemide injected (2.5 mg/kg) to anesthetized rabbits, control rabbits, and rabbits receiving warfarin (50 mg/kg) alone or with albumin (187.5 mg/kg)

Control (n = 6)Warfarin (n = 6)Warfarin + Albumin (n = 6)
Unbound drug (%)1.8  ± 0.47.0  ± 1.02-a 2.3  ± 0.4
T 1/2 (min)14.9  ± 2.117.3  ± 1.216.2  ± 1.2
C max(μg/ml)23.7  ± 1.617.4  ± 1.12-a 23.0  ± 2.5
AUC 0–60(μg·min·ml−1)202  ± 172243  ± 23298  ± 34
Vd ss (ml/kg)172  ± 19215  ± 19170  ± 7
Cl s(ml·min−1·kg−1)11.2  ± 0.810.3  ± 0.69.2  ± 1.0
Cl u(ml·min−1· kg−1)6.0  ± 0.82.8  ± 0.42-a 4.1  ± 0.32-b
Cl m (ml·min−1· kg−1)5.2  ± 0.57.5  ± 0.32-a 5.3  ± 0.8
Urinary recovery (%)47.5  ± 2.725.7  ± 1.943.1  ± 4.1
  • Values are means ± S.E. T1/2, furosemide terminal half-life; Cmax, furosemide maximal plasma concentration; Vdss, furosemide apparent volume of distribution; Cls, Clu, andClm, furosemide total, urinary, and metabolic clearances.

  • 2-a p < .05 compared with control and warfarin + albumin rabbits.

  • 2-b p < .01 compared with control rabbits.