Kinetic parameters of furosemide injected (2.5 mg/kg) to anesthetized rabbits, control rabbits, and rabbits receiving warfarin (50 mg/kg) alone or with albumin (187.5 mg/kg)
| Control (n = 6) | Warfarin (n = 6) | Warfarin + Albumin (n = 6) | |
|---|---|---|---|
| Unbound drug (%) | 1.8 ± 0.4 | 7.0 ± 1.02-a | 2.3 ± 0.4 |
| T 1/2 (min) | 14.9 ± 2.1 | 17.3 ± 1.2 | 16.2 ± 1.2 |
| C max(μg/ml) | 23.7 ± 1.6 | 17.4 ± 1.12-a | 23.0 ± 2.5 |
| AUC 0–60(μg·min·ml−1) | 202 ± 172 | 243 ± 23 | 298 ± 34 |
| Vd ss (ml/kg) | 172 ± 19 | 215 ± 19 | 170 ± 7 |
| Cl s(ml·min−1·kg−1) | 11.2 ± 0.8 | 10.3 ± 0.6 | 9.2 ± 1.0 |
| Cl u(ml·min−1· kg−1) | 6.0 ± 0.8 | 2.8 ± 0.42-a | 4.1 ± 0.32-b |
| Cl m (ml·min−1· kg−1) | 5.2 ± 0.5 | 7.5 ± 0.32-a | 5.3 ± 0.8 |
| Urinary recovery (%) | 47.5 ± 2.7 | 25.7 ± 1.9 | 43.1 ± 4.1 |
Values are means ± S.E. T1/2, furosemide terminal half-life; Cmax, furosemide maximal plasma concentration; Vdss, furosemide apparent volume of distribution; Cls, Clu, andClm, furosemide total, urinary, and metabolic clearances.
↵2-a p < .05 compared with control and warfarin + albumin rabbits.
↵2-b p < .01 compared with control rabbits.