Kinetic parameters of furosemide injected (2.5 mg/kg) to anesthetized rabbits subjected to a functional nephrectomy in absence or in presence of warfarin (50 mg/kg)
| Functional Nephrectomy | ||
|---|---|---|
| Without warfarin (n = 4) | With warfarin (n = 4) | |
| Unbound drug (%) | 1.9 ± 0.1 | 7.5 ± 0.93-a |
| T 1/2 (min) | 56.9 ± 3.2 | 53.4 ± 2.9 |
| C max (μg/ml) | 38.8 ± 2.8 | 42.1 ± 3.4 |
| AUC 0–150(μg·min·ml−1) | 1289 ± 65 | 1516 ± 96 |
| Vd ss (ml/kg) | 121 ± 5 | 103 ± 9 |
| Cl s(ml·min−1·kg−1) | 1.68 ± 0.1 | 1.50 ± 0.1 |
Values are means ± S.E. T1/2, furosemide terminal half-life; Cmax, maximal furosemide plasma concentration; Vdss, furosemide apparent volume of distribution; Cls, furosemide systemic clearance.
↵3-a p < .001 compared with control rabbits.