Menadione-dependent N-oxide reduction by liver cytosols from several mammalian species
| Species | Menadione | Imipramine Formed2-anmol/30 min/mg protein | |
|---|---|---|---|
| NADPH | NADH | ||
| Rabbit | − | 0.6 ± 0.1 | 0.5 ± 0.1 |
| + | 9.0 ± 1.0 | 8.7 ± 1.1 | |
| Guinea pig | − | 0.7 ± 0.1 | 0.5 ± 0.1 |
| + | 6.4 ± 0.7 | 5.3 ± 0.7 | |
| Mouse | − | 0.7 ± 0.3 | 0.8 ± 0.2 |
| + | 14.1 ± 1.3 | 11.1 ± 1.0 | |
| Hamster | − | 0.6 ± 0.2 | 0.7 ± 0.2 |
| + | 8.6 ± 1.0 | 8.9 ± 0.9 | |
Each value represents the mean ± S.D. of four animals.
↵2-a The assay was carried out anaerobically using 0.2 ml of liver cytosol from several animal species as described inMaterials and Methods.