Inhibitor | Inhibition Type | Ki |
---|---|---|
Ketoconazole | ||
Liver | Noncompetitive | 14.9 ± 6.7 nM |
Intestine | Noncompetitive | 17.0 ± 7.9 nM |
Fluconazole | ||
Liver | Noncompetitive | 10.7 ± 4.2 μM |
Intestine | Noncompetitive | 10.4 ± 2.9 μM |
↵1-a n = 3 for each Kidetermination (mean ± S.D.), using microsomes with no detectable CYP3A5.