Table 5

Comparison between predicted value and observed value of increase in ratio of plasma concentration of MDZ

InhibitorRp 1 + Cpf/KiRh 1 + Chf/KiR AUC′/AUC
ITZ1.03 ∼ 1.051.73 ∼ 1.972.14
Cimetidine5-a 1.542.042.5
  • The increase ratios, Rp, and RH were calculated from Cpf using eq. 19 and CHf using eq. 17. AUC′/AUC is observed value calculated from Fig. 3.

  • 5-a Cited from our report concerning the interaction between histamine H2 receptor antagonists and MDZ (Takedomi et al., 1998).