Sequence alignment of CYP102 with CYP2B6 and various other human CYPs2-a
| Sequence | CYP2B6 Identity | Residues | |||
|---|---|---|---|---|---|
| Isoform | G helix | Loop | H helix | ||
| % | |||||
| CYP2B6 | H S V E K H R E T | L D P S - A P K D | L I D | 247–266 | |
| CYP2A6 | K KV E H N Q R T | L D P N - SP R D | F I D | 50 | 250–269 |
| CYP2F1 | H S V H D H Q A S | L D P R - S P RD | F I Q | 50 | 247–266 |
| CYP2E1 | E R V K E H H Q S | L D P N - C P RD | L T D | 45 | 248–267 |
| CYP2C8 | E K V K E H Q A S | L D V N - N P RD | F I D | 40 | 246–265 |
| CYP2C9 | E K V K E H Q ES | M D M N - N P QD | F I D | 40 | 246–265 |
| CYP2C19 | E K V K E H Q ES | M D I N - N P RD | F I D | 40 | 246–265 |
| CYP2D6 | E L L T E H R MT | W D P A Q P P RD | L T E | 40 | 253–273 |
| CYP1A2 | K T V Q E H Y Q D | F D K N - S V R D | I T G | 20 | 266–285 |
| CYP3A4 | R M K E S R LE D | T Q K H - R V - D | F L Q | 15 | 255–273 |
| CYP102 | K I I A D R K A S | G E - Q - S - D D | L L T | 10 | 218–235 |
↵2-a Assignment of helices G and H to mammalian CYPs and sequence alignments are based on the three-dimensional structure of CYP102 (Lewis, 1995, 1998). Residues identical to CYP2B6 are shown in bold, and percentage of identity of overlapping residues is indicated.