Comparison of pharmacokinetic data for retigabine and retigabine N-glucuronide in healthy volunteers after the indicated single dose of retigabine
| Subject | Dose (mg) | Retigabine | RetigabineN-glucuronide | f | ||
|---|---|---|---|---|---|---|
| AUC (μM/h) | T1/2 (h) | AUC (μM/h) | T1/2 (h) | |||
| 1 | 200 | 9.8 | 11.4 | 238 | 12.3 | 24.4 |
| 2 | 600 | 43.9 | 10.7 | 710 | 8.3 | 16.2 |
| 3 | 600 | 39.2 | 8.0 | 607 | 9.9 | 15.5 |
AUC: area under curve; T1/2: terminal half life; f = AUCRetigabine N-glucuronide/AUCRetigabine.