Table 2

Pharmacokinetics of CSA in male CF-1 mice

ParameterAnimal Group
PGP (+/+)PGP (−/−)
AUC(0–24) (ng · h/ml)1783.31984.7
Cl (ml/min/kg)9.38.4
Vdss (l/kg)2.12.3
T 1/2 (h)3.993.32
MRT (h)3.684.49
  • Blood AUC (0–24 h) was calculated by the linear trapezoidal rule using concentrations (n = 3) at each time point after i.v. administration.