Statistical analysis of CYP3A inhibition at various protein concentrations by antifungal inhibitors
Regression Model | Step | Clotrimazole | Ketoconazole | Fluconazole | |||
---|---|---|---|---|---|---|---|
r2 | P | r2 | P | r2 | P | ||
First Analysis: | |||||||
Protein Conc. | 1 | 0.60 | 0.001 | 0.39 | 0.006 | 0.06 | 0.3881-a |
+ Inhibitor Conc. | 2 | 0.81 | 0.003 | 0.94 | 0.001 | 0.96 | 0.001 |
Second Analysis: | |||||||
Inhibitor Conc. | 1 | 0.21 | 0.0851-a | 0.55 | 0.001 | 0.90 | 0.001 |
+ Protein Conc. | 2 | 0.81 | 0.001 | 0.94 | 0.001 | 0.96 | 0.001 |
Predictor (protein and inhibitor concentrations) and response (percent inhibition) variables were log transformed. Stepwise linear regression was performed using SPSS Version 7.5 (SPSS Inc., Chicago, IL).
↵1-a Non-significant, p > .05.