Effect of different xanthates on the 7-EFC O-deethylation activity of P-450 2E1
| Xanthate | KI | kinactivation | T1/2 |
|---|---|---|---|
| μM | min−1 | min | |
| C2 | 650 | 0.04 | 18 |
| C8 | 60 | 0.12 | 6.0 |
| D609 | 684 | 0.08 | 8.3 |
| Cyclohexyl | 110 | 0.02 | 29 |
| C14 | 1000 | 0.33 | 2.1 |
Assay conditions were as described in Experimental Procedures. The data shown represent the mean from three separate experiments.